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Updated: Jan 24, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
Published on: September 16, 2014
Coordination polymers of Tb3+/Nucleotide as smart chemical nose/tongue toward pattern-recognition-based and
Xin-Yue Han1, Qian-Xi Fan1, Zi-Han Chen1
1School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
Abstract:
The abundant functional groups on guanosine monophosphate (GMP) make it possible to interact with various metal ions. The subtle difference in the structure of GMP and deoxy-guanosine monophosphate (dGMP) coupled with Tb3+ can be readily exploited to form two coordination polymers, which have been unveiled as two time-resolved fluorescence (TRF) sensing reporters (Tb-GMP and Tb-dGMP) in our study. Based on this finding, herein, we have proposed a novel TRF orthogonal sensing array (Tb-GMP/dGMP) for pattern-recognition-based sensing of various metal ions. In addition, upon integration of some thiol-affinity metal ions, Tb-GMP/dGMP can be further extended to construct two metal ion-involved pattern-recognition-based sensor arrays (Tb-GMP/dGMP-Cu, Tb-GMP/dGMP-Ag) for the TRF sensing different levels of disease-relevant biothiols in biofluids, illustrating the powerful and multifunctional capabilities of the Tb-GMP/dGMP system and would inspire simpler and more widespread designs of chemical nose/tongue-based applications.
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