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Updated: Jan 24, 2026
10:15
Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
Published on: November 1, 2019
13.3K
Developments in the anticancer activity of structurally modified curcumin: An up-to-date review
Fiona C Rodrigues1, N V Anil Kumar2, Goutam Thakur1
1Department of Biomedical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576 104, India.
European Journal of Medicinal Chemistry
|May 27, 2019
Summary
Researchers are developing novel curcuminoids, which are modified forms of curcumin, to enhance its anticancer efficacy. These new compounds aim to overcome curcumin's poor bioavailability and absorption issues for improved therapeutic outcomes.
Area of Science:
- Pharmacology
- Natural Products Chemistry
Background:
- Curcumin, a polyphenol from turmeric, exhibits significant anticancer properties by regulating multiple molecular targets involved in cell signaling.
- Its therapeutic potential is hindered by poor bioavailability, low absorption, and rapid elimination.
- Structural modifications are being explored to create superior curcuminoids with enhanced efficacy.
Purpose of the Study:
- To review analogues and derivatives of curcumin reported since 2014.
- To highlight compounds with improved anticancer activity compared to native curcumin.
- To provide a comprehensive account of advancements in curcuminoid research for cancer therapy.
Main Methods:
- Literature review of scientific publications from 2014 onwards.
- Analysis of reported curcumin analogues and derivatives.
- Evaluation of studies demonstrating enhanced anticancer activity and improved physicochemical properties.
Main Results:
- Numerous curcumin analogues and derivatives have been synthesized and investigated.
- Many of these modified compounds show enhanced anticancer activity.
- Improved bioavailability and pharmacokinetic profiles are observed in several novel curcuminoids.
Conclusions:
- Structural modification of curcumin leads to superior curcuminoids with enhanced anticancer potential.
- These novel compounds offer a promising strategy to overcome the limitations of curcumin.
- Further research into curcuminoid development could lead to more effective cancer therapeutics.
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