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Related Concept Videos

Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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Satellite Stem Cells and Muscular Dystrophy01:21

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Microscopic Anatomy of Skeletal Muscles01:13

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Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
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Relaxation of Skeletal Muscles01:29

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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
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Related Experiment Video

Updated: Jan 14, 2026

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo
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Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo

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Satellite cells in denervated muscles.

V Verma

    Experientia
    |January 15, 1979
    PubMed
    Summary

    In denervated frog muscle, satellite cells multiply. A connection between satellite cells and Schwann cells may support Schwann cell survival after denervation.

    Area of Science:

    • Muscle biology
    • Cellular neuroscience

    Background:

    • Striated muscle denervation leads to satellite cell proliferation.
    • Schwann cells are crucial for nerve and muscle interactions.

    Purpose of the Study:

    • To investigate the relationship between satellite cells and Schwann cells in denervated muscle.
    • To explore the potential role of cell connections in Schwann cell survival.

    Main Methods:

    • Microscopic observation of denervated frog muscle.
    • Analysis of cell-cell interactions.

    Main Results:

    • Observed a liaison between satellite cells and Schwann cells.
    • This connection was located in front of the post-synaptic membrane.

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    Isolation, Culture, and Transplantation of Muscle Satellite Cells
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    Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles
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    Conclusions:

    • Cell connections between satellite cells and Schwann cells are present in denervated muscle.
    • These interactions likely contribute to Schwann cell subsistence in denervated muscle.