Related Experiment Video

Updated: Jan 24, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

10.2K

Association between early life (prenatal and postnatal) antibiotic administration and coeliac disease: a systematic

Maciej Kołodziej1, Bernadeta Patro-Gołąb1, Dorota Gieruszczak-Białek1

  • 1Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.

Archives of Disease in Childhood
|May 27, 2019
PubMed

Insights

Early life antibiotic exposure, both before and after birth, does not appear to increase the risk of developing coeliac disease (CD). This systematic review found no conclusive evidence linking antibiotic use in infancy to CD development.

Area of Science:

  • Gastroenterology
  • Pediatrics
  • Epidemiology

Background:

  • Antibiotic use during early life is common.
  • The potential impact of antibiotic exposure on the development of coeliac disease (CD) and CD autoimmunity remains unclear.
  • Understanding this association is crucial for public health guidance.

Purpose of the Study:

  • To systematically review observational studies investigating the association between prenatal and/or postnatal antibiotic exposure and the risk of coeliac disease (CD) or CD autoimmunity.
  • To synthesize current evidence regarding the link between early antibiotic use and CD development.

Main Methods:

  • A systematic review of observational studies (cohort, cross-sectional, case-control) was conducted.
  • Studies were identified through searches of PubMed and Embase databases up to December 2018.
  • Inclusion criteria focused on studies assessing antibiotic exposure in early life and subsequent CD or CD autoimmunity diagnosis.

Main Results:

  • Six studies met the inclusion criteria.
  • Two large cohort studies found no association between prenatal antibiotic exposure and CD risk.
  • Studies on postnatal antibiotic exposure yielded contradictory results, with one Italian cohort showing a significant positive association, while another large study found no link with CD autoimmunity.

Conclusions:

  • Current evidence does not support a link between prenatal antibiotic exposure and an increased risk of coeliac disease.
  • The association between postnatal antibiotic exposure and coeliac disease risk is not definitively established, with conflicting findings across studies.
  • Further research may be needed to clarify the complex relationship between early antibiotic exposure and immune-mediated conditions like CD.
Abstract

Keywords:
antibioticsceliac diseasechildrenprenatalsystematic review

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.8K
Antibiotic Dereplication Using the Antibiotic Resistance Platform10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.6K

Related Concept Videos

Half-life of a Reaction02:42

Half-life of a Reaction

The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
38.8K
Antibiotic Selection00:57

Antibiotic Selection

Overview
59.6K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
Characteristics of Life01:23

Characteristics of Life

Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
257.4K
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
72.2K