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Updated: Jan 24, 2026
14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
21.9K
Chronified Pain Following Operative Procedures.
Dominik Geil1, Claudia Thomas, Annette Zimmer
1Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital.
Deutsches Arzteblatt International
|May 28, 2019
Summary
Local and regional anesthesia, along with intravenous lidocaine, can reduce chronic post-surgical pain (CPSP) incidence. These methods are effective for specific surgeries but require informed consent for lidocaine use.
Area of Science:
- Anesthesiology
- Pain Management
- Surgical Outcomes
Background:
- Chronic post-surgical pain (CPSP) affects about 10% of surgical patients, significantly impacting quality of life.
- CPSP is defined as pain persisting for at least three months after surgery.
- Perioperative anesthetic interventions may reduce the occurrence of CPSP.
Purpose of the Study:
- To review the effectiveness of local and regional anesthetic techniques and intravenous lidocaine in preventing chronic post-surgical pain (CPSP).
Main Methods:
- Selective literature review, including two Cochrane Reviews.
- Discussion of local, regional, and intravenous anesthetic techniques for pain management.
Main Results:
- Key risk factors for CPSP include preoperative pain, opioid use, catastrophizing, nerve injury, and severe acute postoperative pain.
- Local/regional anesthesia significantly reduces CPSP after thoracotomy (NNTB=7), breast surgery (NNTB=7), and cesarean sections (NNTB=19).
- Intravenous lidocaine also demonstrates efficacy in lowering CPSP incidence across various procedures.
Conclusions:
- Local/regional anesthesia and intravenous lidocaine are effective in reducing CPSP incidence for specific surgical procedures.
- Intravenous lidocaine for CPSP prevention is an off-label use requiring informed consent.
- The evidence supporting these preventative measures is of low to medium quality.
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