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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Vision and Vision-Related Measures in Progressive Multiple Sclerosis
Yael Backner1, Panayiota Petrou2, Haya Glick-Shames1
1fMRI Unit, Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Frontiers in Neurology
|May 28, 2019
Summary
Visual measures effectively track damage in progressive multiple sclerosis (MS). Optic neuritis (ON) impacts vision long-term, with motion perception useful for assessing myelination and axonal loss in MS patients.
Area of Science:
- Neuroscience
- Ophthalmology
- Clinical Neurology
Background:
- Visual system assessment is increasingly used for multiple sclerosis (MS) prognosis and tracking.
- Optic neuritis (ON) and posterior visual pathway damage are common in MS.
- Disease progression in MS may alter visual pathway assessment compared to early stages.
Purpose of the Study:
- To evaluate if vision-related tools reflect demyelination and axonal damage in progressive MS.
- To determine the utility of visual measures for patient assessment in progressive MS.
- To investigate how accumulated disease load impacts visual pathway assessment.
Main Methods:
- Forty-eight progressive MS patients (with/without prior ON) underwent behavioral tests, visual evoked potentials (VEP), optical coherence tomography (OCT), and MRI.
- Data collected at two time-points were analyzed for stability and correlations.
- Comparison between affected/fellow eyes in ON patients and ON/non-ON eyes.
Main Results:
- All visual measures demonstrated stability between visits.
- Significant differences observed in visual measures between affected and fellow eyes in ON patients.
- Motion perception correlated with VEP latencies, indicating myelination status.
- Retinal nerve fiber layer thickness correlated with non-ON eye latencies, suggesting axonal loss.
Conclusions:
- Optic neuritis leaves a lasting impact on the visual system in progressive MS.
- Motion perception is a valuable tool for assessing visual pathway integrity in progressive MS.
- Axonal loss contributes to visual pathway damage in non-ON eyes, while demyelination is key in ON eyes.
- Assessed visual measures are valid tools for therapeutic studies in MS.
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