Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
3.6K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.6K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.5K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.5K
The Pineal Gland01:02

The Pineal Gland

4.9K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
4.9K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.3K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic landscape of crotonylation and acetylation in pig testes across male reproduction.

Journal of proteomics·2026
Same author

Single-cell analysis reveals cellular heterogeneity and molecular features during postnatal pig testis development.

BMC genomics·2025
Same author

Pleistocene terrestrial warming trend in East Asia linked to Antarctic ice sheets growth.

Nature communications·2025
Same author

Orbital- and millennial-scale Asian winter monsoon variability across the Pliocene-Pleistocene glacial intensification.

Nature communications·2024
Same author

Concurrent Asian monsoon strengthening and early modern human dispersal to East Asia during the last interglacial.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Heterologous expression of Zygophyllum xanthoxylon zinc finger protein gene (ZxZF) enhances the tolerance of poplar photosynthetic function to drought stress.

Plant physiology and biochemistry : PPB·2023

Related Experiment Video

Updated: Jan 24, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

8.8K

Dynamic Transcriptome Analysis Reveals Potential Long Non-coding RNAs Governing Postnatal Pineal Development in Pig.

Yalan Yang1, Rong Zhou2, Wentong Li1,2

  • 1Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Sciences and Engineering, Foshan University, Foshan, China.

Frontiers in Genetics
|May 28, 2019
PubMed
Summary

This study reveals dynamic changes in messenger RNA (mRNA) and long noncoding RNA (lncRNA) during pig pineal gland development. These findings highlight the crucial role of lncRNAs in regulating pineal gland maturation and function.

Keywords:
long noncoding RNApigpineal glandpostnatal developmenttranscriptome

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.1K
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
10:32

Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl

Published on: August 14, 2013

8.3K

Related Experiment Videos

Last Updated: Jan 24, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

8.8K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.1K
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
10:32

Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl

Published on: August 14, 2013

8.3K

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Pineal gland development involves complex gene expression.
  • Limited molecular data exists for postnatal pineal gland, especially concerning long noncoding RNAs (lncRNAs).

Purpose of the Study:

  • To comprehensively characterize the postnatal pig pineal gland transcriptome.
  • To investigate dynamic mRNA and lncRNA expression patterns during development.
  • To identify lncRNAs involved in pineal gland maturation.

Main Methods:

  • Strand-specific RNA sequencing (RNA-seq) was employed.
  • Transcriptome profiling was performed at three developmental stages: infancy, puberty, and adulthood.
  • Gene Ontology (GO) analysis and co-expression network analysis were utilized.

Main Results:

  • 21,448 mRNAs and 8,166 novel lncRNAs were identified.
  • 3,573 mRNAs and 851 lncRNAs showed significant dynamic regulation during maturation.
  • Differentially expressed genes were enriched in pathways related to ion transport and synaptic transmission, emphasizing calcium signaling's role.

Conclusions:

  • This study provides the first comprehensive overview of postnatal pig pineal gland transcriptome dynamics.
  • Dynamic lncRNA regulation significantly impacts pineal gland physiology during developmental transitions.
  • lncRNAs are implicated in regulating key developmental processes within the pineal gland.