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A Reversibly Responsive Fluorochromic Hydrogel Based on Lanthanide-Mannose Complex.

Ke Meng1, Chi Yao1, Qianmin Ma1

  • 1Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE) School of Chemical Engineering and Technology Tianjin University Tianjin 300350 P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 28, 2019
PubMed
Summary
This summary is machine-generated.

This study presents a novel lanthanide-based hydrogel that dynamically changes its fluorescence in response to iron ions. This smart material offers a reversible "On/Off" optical switch for advanced applications.

Keywords:
3D cell culturefluorochromic materialshydrogelslanthanide–mannose complexresponsive materials

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Dynamic fluorochromic materials are crucial for developing advanced sensors and luminescent devices.
  • Lanthanide-based materials offer unique luminescent properties but require careful design for stimulus responsiveness.

Purpose of the Study:

  • To design and synthesize a lanthanide-containing polymeric hydrogel with tunable fluorescence.
  • To investigate the hydrogel's response to external stimuli, specifically metal ions.
  • To demonstrate the hydrogel's potential in biological applications requiring reversible optical switching.

Main Methods:

  • Preparation of a fluorochromic hydrogel using a lanthanide-mannose complex within a gelation matrix.
  • Investigation of the hydrogel's fluorescent emission changes in response to Fe2+.
  • Evaluation of the reversible 'On/Off' switching mechanism using Fe2+ and ethylenediaminetetraacetic acid (EDTA).

Main Results:

  • The lanthanide-mannose complex exhibited tunable fluorescent emission responsive to Fe2+, attributed to the inhibition of the 'antenna effect'.
  • The hydrogel demonstrated a reversible 'On/Off' fluorochromic response to the presence and removal of Fe2+ (via EDTA).
  • The developed hydrogel was proven to be nontoxic and biocompatible.

Conclusions:

  • A novel, biocompatible, and reversible fluorochromic hydrogel based on lanthanides was successfully developed.
  • The hydrogel's tunable fluorescence response to Fe2+/EDTA opens avenues for smart optical materials.
  • Demonstrated potential as an in situ 3D cell culture extracellular matrix with reversible optical switching capabilities.