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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Jan 24, 2026

Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors
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Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors

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Peripheral blood stem cell mobilization; a look ahead.

Louis M Pelus1, Hal E Broxmeyer1

  • 1Department of Microbiology & Immunology, Indiana University School of Medicine, 950 W Walnut Street, R2-301, Indianapolis, IN 46202.

Current Stem Cell Reports
|May 28, 2019
PubMed
Summary

Mobilizing hematopoietic stem cells (HSCs) is crucial for transplantation. New strategies are being developed to improve the efficiency of HSC collection and engraftment, addressing challenges in achieving sufficient stem cell numbers.

Keywords:
HSC egressHematopoietic stem cellsPeripheral blood stem cell mobilizationhigh engrafting stem cellshypoxic collectionstem cell collection

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Last Updated: Jan 24, 2026

Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors
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Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector
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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Transplantation Medicine

Background:

  • Mobilized peripheral blood is the primary source for stem and progenitor cells in hematologic transplantation.
  • Achieving adequate stem cell numbers for successful transplantation can be challenging in some patients and donors.
  • There is a continuous need for novel strategies that enhance stem cell mobilization, collection, and engraftment, particularly those that are rapid and cost-effective.

Purpose of the Study:

  • To review the scientific basis of stem cell mobilization.
  • To highlight novel and improved strategies for efficient collection and engraftment of mobilized stem cells.

Main Methods:

  • Review of current scientific literature on stem cell mobilization.
  • Identification and evaluation of new agents and strategies targeting stem cell egress and collection.
  • Analysis of methods to optimize stem cell engraftment.

Main Results:

  • New insights into the complex mechanisms of stem cell mobilization have emerged.
  • Agents targeting novel pathways for hematopoietic stem cell (HSC) egress are under investigation.
  • Strategies to collect more potent HSCs and optimize collection and engraftment are being evaluated.

Conclusions:

  • Novel agents and effective strategies have been identified to overcome current limitations in hematopoietic stem cell mobilization and transplantation.
  • These advancements hold the potential to facilitate stem cell collection and broaden the application of mobilized stem cells.