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Direct Prebiotic Pathway to DNA Nucleosides.

Jennifer S Teichert1,2, Florian M Kruse1, Oliver Trapp1,2

  • 1Department of Chemistry, Ludwig-Maximilians-University Munich, Butenandtstr. 5-13, 81377, Munich, Germany.

Angewandte Chemie (International Ed. in English)
|May 28, 2019
PubMed
Summary

Scientists discovered a prebiotic pathway to deoxyribonucleosides, crucial for DNA formation. This finding suggests DNA-based life may have originated much earlier than previously thought.

Keywords:
nucleosidesorganocatalysisorigin of lifepolymersprebiotic chemistry

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Area of Science:

  • Origin of Life studies
  • Prebiotic Chemistry
  • Molecular Evolution

Background:

  • RNA is hypothesized to be key in early life.
  • The transition from RNA to DNA requires ribonucleotide reductase, a step with an unknown origin.
  • An abiotic pathway to DNA-based life remains undiscovered.

Purpose of the Study:

  • To investigate a prebiotic pathway for deoxyribonucleoside formation.
  • To identify potential DNA progenitors from abiotic molecules.

Main Methods:

  • Condensation reactions of canonical purine and pyrimidine bases with acetaldehyde and sugar precursors.
  • Experiments conducted under prebiotic conditions in water.
  • Analysis of regio- and stereoselectivity of product formation.

Main Results:

  • Successful formation of deoxyribonucleosides from all canonical bases under prebiotic conditions.
  • High regio- and stereoselectivity observed in the synthesis.
  • Identification of deoxyapionucleosides (DApiNA) as a potential DNA progenitor.

Conclusions:

  • A continuous prebiotic pathway to deoxyribonucleosides has been established.
  • The findings suggest that the DNA world could have evolved significantly earlier than previously assumed.
  • This research provides a plausible route for the emergence of DNA-based life from simple abiotic molecules.