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The role of fosfomycin in osteoarticular infection

L Morata, A Soriano1

  • 1Alex Soriano, Hospital Clínic de Barcelona. IDIBAPS. Universidad de Barcelona, Spain. asoriano@clinic.cat.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|May 28, 2019
PubMed

Insights

Fosfomycin shows promising activity against resistant Gram-positive and Gram-negative bacteria causing osteoarticular infections. Its favorable properties and clinical data suggest it is a viable treatment option for these challenging infections.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Orthopedics

Background:

  • Osteoarticular infections, including osteomyelitis and septic arthritis, are increasingly complicated by multidrug-resistant bacterial strains.
  • Gram-positive microorganisms are the most frequent culprits in these infections.

Purpose of the Study:

  • To review the efficacy of fosfomycin in treating osteoarticular infections.
  • To analyze fosfomycin's in vitro activity, pharmacokinetic/pharmacodynamic properties, and clinical experience in bone infections.

Main Methods:

  • In vitro susceptibility testing against relevant pathogens.
  • Review of pharmacokinetic and pharmacodynamic data.
  • Analysis of experimental osteomyelitis and foreign body infection models.
  • Evaluation of clinical case studies and trials.

Main Results:

  • Fosfomycin demonstrates broad-spectrum activity, including against multidrug-resistant Gram-positive and Gram-negative pathogens.
  • The drug exhibits favorable properties for bone penetration, such as low protein binding and molecular weight.
  • Experimental models and clinical data support its effectiveness in osteomyelitis and related infections.

Conclusions:

  • Fosfomycin is an effective therapeutic option for osteoarticular infections, particularly those caused by resistant bacteria.
  • Its pharmacokinetic profile and bone dissemination make it suitable for treating bone and joint infections.

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