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Fosfomycin in the pediatric setting: Evidence and potential indications.
F Baquero-Artigao1, T Del Rosal Rabes
1Fernando Baquero-Artigao, Servicio de Pediatría, Enfermedades Infecciosas y Patología Tropical. Hospital Universitario La Paz. Paseo de la Castellana, 261. 28046 Madrid. Spain. fbaqueroartigao@gmail.com.
Fosfomycin is a safe antibiotic for children, effective against multidrug-resistant bacteria. It is a valuable option for urinary tract infections and other serious infections, including osteomyelitis and bacteremia.
Area of Science:
- Pediatric infectious diseases
- Antimicrobial therapy
- Pharmacology
Background:
- Limited pediatric experience with fosfomycin.
- Renewed interest due to broad spectrum and safety.
- Emergence of multidrug-resistant bacteria necessitates new treatment options.
Purpose of the Study:
- To review the current and potential pediatric applications of fosfomycin.
- To highlight its utility in treating infections caused by resistant pathogens.
- To discuss its role in combination therapy for complex infections.
Main Methods:
- Literature review of pediatric fosfomycin use.
- Analysis of fosfomycin's spectrum of activity and safety profile.
- Evaluation of clinical evidence for various pediatric infections.
Main Results:
- Primary indication: community-acquired lower urinary tract infections.
- Effective against extended-spectrum beta-lactamase-producing enterobacteria.
- Good tissue penetration (including bone) for osteomyelitis treatment.
- Useful in combination therapy for multidrug-resistant Gram-negative bacteremia, S. aureus (MRSA), and VRE.
- Potential role in staphylococcal endocarditis, CNS infections, and nosocomial pneumonia.
Conclusions:
- Fosfomycin is a promising antibiotic for pediatric use, particularly for resistant infections.
- Its safety profile and broad spectrum make it a valuable therapeutic option.
- Further research and clinical experience are warranted to expand its indications.
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