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Updated: Jan 24, 2026
08:31
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
596
Acute Lymphoblastic Leukemia in Routine Practice: A Turkish Multicenter Study
Rafiye Çiftçiler1, Ömür Gökmen Sevindik2, Ali İrfan Emre Tekgündüz3
1Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey
Summary
This study analyzed adult acute lymphoblastic leukemia (ALL) patients in Turkey, finding that while most achieved remission, outcomes require improvement. Real-world data from this multicenter analysis offers insights into the Turkish ALL patient profile.
Area of Science:
- Hematology
- Oncology
Background:
- Significant advancements in adult acute lymphoblastic leukemia (ALL) management have been made.
- However, treatment outcomes in routine clinical practice remain suboptimal.
Purpose of the Study:
- To evaluate clinical features, treatment protocols, and outcomes in a large cohort of adult ALL patients in Turkey.
- To provide real-world data on the Turkish ALL patient population.
Main Methods:
- Retrospective analysis of 288 adult ALL patients diagnosed and treated between 2003 and 2017 across ten Turkish centers.
- Patient classification based on treatment period, Philadelphia chromosome status, treatment regimen, and allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Main Results:
- The cohort comprised 224 B-ALL and 64 T-ALL cases, with a median follow-up of 18.2 months.
- Philadelphia chromosome positivity was observed in 21.9% of patients, and 18.8% received allo-HSCT.
- Complete remission was achieved in 76.0% post-induction chemotherapy, with a median overall survival of 47.7 months.
Conclusions:
- Multicenter studies are crucial for understanding disease-specific clinical characteristics.
- This study contributes valuable real-world data to the literature on the Turkish ALL patient profile.
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