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An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
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Paediatric brain abscesses: a single centre experience.

Samuel Hall1, Shirley Yadu2, Benjamin Gaastra1

  • 1Department of Neurosurgery, University Hospitals Southampton NHS Foundation Trust , Southampton , UK.

British Journal of Neurosurgery
|May 28, 2019
PubMed
Summary
This summary is machine-generated.

Pediatric brain parenchymal abscesses are rare but serious infections. This study found that surgical intervention and antibiotics lead to favorable outcomes, with Streptococcus being the most common cause.

Keywords:
Brain abscessburr hole aspirationcranial infectionpaediatric neurosurgery

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Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Neurosurgery

Background:

  • Brain parenchymal abscesses are uncommon but severe pediatric infections.
  • Effective management typically involves surgery and prolonged antibiotic therapy.

Purpose of the Study:

  • To review a single center's experience managing pediatric brain parenchymal abscesses.
  • To correlate patient demographics, microbiology, interventions, and outcomes.

Main Methods:

  • Retrospective review of 24 pediatric patients (2003-2017) with confirmed brain parenchymal abscess.
  • Data collected included abscess location, microbiology, surgical approach, and Glasgow Outcome Score (GOS) at 3 months.

Main Results:

  • Fifty percent of abscesses were frontal lobe. Streptococcus was the most common pathogen.
  • Nineteen patients had an identifiable preceding infection.
  • All patients underwent surgery; 18/20 with 3-month follow-up achieved GOS 5, with no mortality.

Conclusions:

  • Pediatric brain parenchymal abscess is rare, often preceded by infection.
  • Streptococcus is a frequent causative organism, guiding antimicrobial selection.
  • Surgical intervention and antibiotics are associated with favorable outcomes and no mortality.