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The relationship between the carotid and coronary artery stenosis: a study based on angiography
1a Department of Neurology, Capital Medical University Affiliated Anzhen Hospital , Beijing , China.
Insights
Angiography revealed a significant link between carotid artery stenosis (CAS) and coronary artery stenosis disease (COAS). More severe CAS correlated with a greater number of affected coronary arteries, highlighting a critical association.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Vascular Surgery
Background:
- Carotid artery stenosis (CAS) and coronary artery stenosis disease (COAS) are frequently associated.
- Previous studies relied on non-invasive methods to assess this link.
- Angiographic evaluation provides a more direct assessment of both conditions.
Purpose of the Study:
- To investigate the relationship between CAS and COAS using digital subtraction angiography (DSA) and coronary angiography (CAG).
- To identify independent risk factors for severe COAS.
- To determine if the severity of CAS correlates with the extent of COAS.
Main Methods:
- Retrospective analysis of 231 patients undergoing same-day DSA and CAG.
- Patients stratified by stenosis severity: mild (<50%), moderate (50-69%), severe (70-99%), and occlusion (100%).
- Correlation and risk factor analysis performed using Spearman and Kendall's tau-b tests.
Main Results:
- Independent risk factors for severe COAS (≥70%) included age, sex, prior cerebral infarction, coronary heart disease, and coronary artery surgery.
- A significant association was found between CAS and COAS (Spearman r = 0.333, P < 0.01).
- Increased severity of CAS was directly correlated with increased COAS involvement (Kendall's tau-b = 0.294, p < 0.01).
Conclusions:
- Digital subtraction angiography confirmed the association between carotid artery stenosis and coronary artery stenosis disease.
- The severity of carotid artery stenosis is directly proportional to the number of affected coronary arteries.
- These findings underscore the importance of considering concurrent coronary artery disease in patients with significant carotid stenosis.
Abstract:
Objective: Previous studies have demonstrated a strong association between carotid artery stenosis (CAS) and coronary artery stenosis disease (COAS). However, prior evaluated methods are non-invasive examinations. This study was aimed to access the relationship between CAS and COAS by the means of angiography. Methods: This is a single-center, retrospectively reviewed study based on digital subtraction angiography (DSA) of carotid artery and coronary artery angiography (CAG). We collected a total of 231 patients undergoing DSA and CAG at the same-day between June 2013 and May 2015. The patients were stratified according to the degree of CAS and COAS, mild stenosis <50%, moderate stenosis 50-69%, severe stenosis 70-99%, occlusion 100%. The correlation of CAS with COAS, as well as the risk factors, was analyzed. Results: A total of 231 patients was enrolled in this study, male 71.9% (166/231). The age ranges from 32 to 80, mean age 60.06 ± 9.98. Of these patients, 79 patients were severe CAS and 128 patients were severe COAS. Statistical analysis demonstrated that the independent risk factors of severe COAS ≥70%, were age, sex, previous cerebral infraction, coronary heart diseases, and coronary artery surgery. CAS was associated with COAS (Spearman r = 0.333, P < 0.01). The more serious the CAS, the more involved COAS (Kendall's tab-b = 0.294, p < 0.01). Conclusions: The DSA confirmed CAS was associated with CAG confirmed COAS. The heavier the CAS is, the more the number of the affected coronary artery.
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