Related Experiment Video

Updated: Jan 24, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.8K

Lenvatinib mesylate to treat hepatocellular carcinoma

L Ielasi1, F Tovoli2, F Piscaglia1

  • 1Unit of Internal Medicine, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Drugs of Today (Barcelona, Spain : 1998)
|May 28, 2019
PubMed

Insights

Hepatocellular carcinoma (HCC) treatment advanced with lenvatinib, a multi-tyrosine kinase inhibitor, offering an alternative to sorafenib. This review details lenvatinib

Area of Science:

  • Hepatocellular carcinoma (HCC) research
  • Oncology drug development
  • Clinical trial analysis

Background:

  • Hepatocellular carcinoma (HCC) presents a significant global health challenge with increasing incidence.
  • Advanced HCC prognosis is poor without effective treatment.
  • Sorafenib, a multi-tyrosine kinase inhibitor, was the first approved frontline therapy for advanced HCC in 2007.

Purpose of the Study:

  • To review preclinical and clinical evidence for lenvatinib in advanced HCC.
  • To highlight key differences between lenvatinib and sorafenib.
  • To provide an overview of lenvatinib's role in advanced HCC management.

Main Methods:

  • Review of preclinical data for lenvatinib.
  • Analysis of clinical trial evidence for lenvatinib, including the REFLECT trial.
  • Comparative analysis of lenvatinib and sorafenib efficacy and safety profiles.

Main Results:

  • Lenvatinib demonstrated noninferiority to sorafenib in the Phase III REFLECT trial.
  • Lenvatinib offers a new frontline systemic treatment option for advanced HCC.
  • Evidence supports lenvatinib as a viable alternative to sorafenib.

Conclusions:

  • Lenvatinib is a key therapeutic option for advanced hepatocellular carcinoma.
  • Understanding lenvatinib's distinct features is crucial for clinical application.
  • The availability of lenvatinib expands treatment choices for advanced HCC patients.
Keywords:
Hepatocellular carcinomaLenvatinibLiver cancer therapyMultitarget tyrosine kinase inhibitorsOncolytic drugs

More Related Videos

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

10.7K
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

6.1K

Related Concept Videos

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.2K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.7K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
Bacterial Transformation01:33

Bacterial Transformation

In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.5K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.1K