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Related Experiment Video

Updated: Jan 24, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice.

Andreas Lundt1, Julien Soos2, Christina Henseler2

  • 1Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices; KBRwyle GmbH.

Journal of Visualized Experiments : Jove
|May 28, 2019
PubMed
Summary

This study details a protocol for recording auditory brainstem-evoked responses (ABRs) in mice, crucial for understanding auditory function and hearing loss. The method aids in evaluating potential treatments for sensorineural hearing loss in preclinical models.

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Area of Science:

  • Neuroscience
  • Audiology
  • Pharmacology

Background:

  • Auditory evoked potentials (AEPs) are vital in clinical neurophysiology for assessing auditory function.
  • AEPs, including brainstem evoked response audiometry (BERA), analyze electroencephalographic responses to auditory stimuli.
  • These techniques are essential in both human diagnostics and preclinical research using animal models.

Purpose of the Study:

  • To provide a detailed protocol for recording auditory brainstem-evoked responses (ABRs) in mice.
  • To establish a standardized method for assessing auditory function in preclinical research.
  • To facilitate the investigation of sensorineural hearing loss and potential therapeutic interventions.

Main Methods:

  • Utilized click and tone-burst stimuli for ABR recording in mice.
  • Focused on pre-experimental animal housing and anesthesia protocols.
  • Employed automated wavelet-based analysis for amplitude growth functions and latency detection.

Main Results:

  • Successfully recorded auditory brainstem-evoked responses (ABRs) in mice.
  • Detailed methodology for ABR recording, filtering, and analysis was established.
  • The protocol enables characterization of auditory function and conduction velocity.

Conclusions:

  • The described protocol offers a comprehensive approach to ABR recording in mice.
  • This method is valuable for preclinical research on auditory function and hearing loss.
  • It supports the evaluation of pharmacological and genetic strategies for treating hearing deficits.