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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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The Intrinsic Apoptotic Pathway01:31

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
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Updated: Jan 24, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
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Intrinsic cancer vaccination.

Yoosoo Yang1, Gi-Hoon Nam2, Gi Beom Kim2

  • 1Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

Advanced Drug Delivery Reviews
|May 28, 2019
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This study introduces intrinsic cancer vaccination to activate the immune system against tumors. This novel immunotherapy strategy enhances the natural cancer-immunity cycle for improved cancer treatment outcomes.

Keywords:
Cancer immunotherapyImmune checkpoint blockadeImmunogenic cell deathPhagocytosis

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Current immunotherapies show promise but are ineffective for immunologically cold tumors.
  • A significant unmet need exists for cancer treatments benefiting all patients.

Purpose of the Study:

  • To propose a novel cancer immunotherapy strategy called "intrinsic cancer vaccination".
  • To leverage cancer cells' genetic instability and neoantigens to activate tumor-specific T cells.

Main Methods:

  • Enhancing phagocytosis of cancer cells by antigen-presenting cells.
  • Inducing immunogenic cancer cell death and subsequent immune responses.
  • Utilizing cancer cell neoantigens for immune system activation.

Main Results:

  • The strategy avoids the need for known tumor-specific antigens, ex vivo manipulation, or adoptive cell therapy.
  • It facilitates efficient presentation of cancer cell neoantigens to the immune system.
  • The approach aims to propagate the natural cancer-immunity cycle.

Conclusions:

  • Intrinsic cancer vaccination offers a novel approach to activate the immune system against cancer.
  • This strategy can be combined with existing treatments to potentially enhance efficacy.
  • It represents a promising avenue for treating immunologically cold tumors.