Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.7K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.7K
Specific Heat01:16

Specific Heat

67.3K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.3K
Density, Specific Weight, Specific Gravity and Compressibility of Fluid01:27

Density, Specific Weight, Specific Gravity and Compressibility of Fluid

1.6K
Density, specific weight, specific gravity, and compressibility are fundamental properties of fluids. Density is the mass per unit volume, characterizing the mass of a fluid system. It influences buoyancy, pressure, flow dynamics, viscosity, thermal conductivity, and sound propagation. For instance, in pipeline design, accurate density measurements ensure that the pipeline can handle the fluid's mass.
Specific weight represents the weight per unit volume and is calculated by multiplying...
1.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.3K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.4K
5.4K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

1.2K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Translation in proximity to forming autophagosomes during sustained autophagy.

Nature communications·2026
Same author

Microautophagy: current understanding of its molecular mechanisms and functions.

Autophagy reports·2026
Same author

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

Science advances·2026
Same author

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1.

Science advances·2026
Same author

Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.

Cell death & disease·2025
Same author

Microautophagy: definition, classification, and the complexity of the underlying mechanisms.

Autophagy·2025
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
Same journal

Endothelial origin of hematopoietic stem cells: Insights from new technologies and unresolved questions.

Seminars in cell & developmental biology·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

35.9K

Glia-specific autophagy dysfunction in ALS.

Laura Strohm1, Christian Behrends1

  • 1Munich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.

Seminars in Cell & Developmental Biology
|May 28, 2019
PubMed
Summary
This summary is machine-generated.

Neurodegenerative diseases like Alzheimer's and Parkinson's involve protein aggregation. Autophagy, a cellular cleanup process, is crucial for clearing these proteins, especially in non-neuronal brain cells called glia.

Keywords:
Amyotrophic lateral sclerosisAstrocyteAutophagyFrontotemporal dementiaGliaInflammationMicrogliaNeurodegenerationOligodendrocyte

More Related Videos

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K

Related Experiment Videos

Last Updated: Jan 24, 2026

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

35.9K
Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
09:00

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

19.2K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Neurodegenerative diseases (NDs) like Alzheimer's and Parkinson's are characterized by neuronal cell death.
  • Protein aggregation (e.g., amyloid beta, tau, alpha-synuclein, TDP-43) is a common pathological hallmark of NDs.
  • Cellular protein quality control systems, including the ubiquitin proteasome system and autophagy, are vital for preventing proteotoxic stress.

Purpose of the Study:

  • To highlight the critical role of autophagy in clearing aggregated proteins implicated in neurodegeneration.
  • To emphasize the understudied contribution of glial cells to the pathogenesis of NDs.
  • To underscore the need for further research into the function of autophagy in glia within the context of neurodegenerative diseases.

Main Methods:

  • Literature review and synthesis of existing research on protein aggregation and autophagy in neurodegeneration.
  • Comparative analysis of the role of autophagy in neurons versus glial cells.
  • Identification of knowledge gaps regarding glial autophagy in NDs.

Main Results:

  • Aggregated proteins are poor substrates for the proteasome and are primarily cleared by autophagy.
  • Autophagy is a critical pathway for neuroprotection against proteotoxic stress.
  • Research on NDs has predominantly focused on neurons, with limited understanding of autophagy's role in glial cells.

Conclusions:

  • Autophagy is a key therapeutic target for neurodegenerative diseases.
  • Glial cells, as major components of the central nervous system, likely play a significant role in NDs.
  • Further investigation into glial autophagy is essential for a comprehensive understanding and treatment of neurodegenerative diseases.