Related Experiment Video
Updated: Jan 24, 2026

05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
589
[Rectal Ulcer Developed in Systemic Lupus Erythematosus without Ischemic Colitis]
Ki Chang Sohn1, Won Gak Heo1, Min Su Chu1
1Departments of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
Summary
Systemic lupus erythematosus (SLE) rarely affects the rectum, causing ulcers without ischemic colitis. This case highlights a rare presentation of SLE in a young female patient.
Area of Science:
- Gastroenterology
- Rheumatology
- Pathology
Background:
- Systemic lupus erythematosus (SLE) is a rare cause of rectal involvement.
- Fewer than 15 cases of SLE-related rectal issues have been documented globally.
- Ischemic colitis is an infrequent complication of SLE in the rectum.
Observation:
- A 17-year-old female presented with abdominal pain and hematochezia.
- Sigmoidoscopy showed a rectal ulcer but no signs of ischemic colitis.
- Infections like cytomegalovirus and bacterial were ruled out.
Findings:
- Rectal biopsy confirmed SLE invasion of the rectal tissue.
- The patient's condition worsened despite treatment.
- This case represents SLE-induced rectal ulceration without ischemic colitis.
Implications:
- This case expands the understanding of rare gastrointestinal manifestations of SLE.
- Highlights the importance of considering SLE in unexplained rectal ulcers, even without typical ischemic colitis.
- Suggests potential challenges in managing SLE-related rectal complications.
Related Concept Videos
Inflammatory Bowel Disease I: Ulcerative Colitis
941
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
941
Drugs for Treatment of Ulcerative Colitis in IBD
482
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
482
Assessing Body Temperature - Rectal
11.8K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
11.8K
Peptic Ulcer Disease II: Pathophysiology
2.0K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.0K
Peptic Ulcer Disease I: Introduction
763
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
763
Peptic Ulcer Disease IV: Management
457
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
457

