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Magnetic hyperthermia adjunctive therapy for fungi: in vitro studies against Candida albicans

Kaushik Suneet1, Shreyas Sridhar2, Purvi Agiwal1

  • 1a Centre for Biosystems Science and Engineering , Indian Institute of Science , Bangalore , India.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|May 29, 2019
PubMed

Insights

Novel magnetic nanofibers loaded with amphotericin B offer a new treatment for fungal keratitis. This approach combines drug delivery with magnetic hyperthermia for enhanced antifungal efficacy.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Ophthalmology

Background:

  • Treating fungal keratitis is challenging due to poor antifungal drug penetration through the corneal epithelium.
  • Developing novel drug delivery systems is crucial for effective ocular infection management.

Purpose of the Study:

  • To develop polycaprolactone-Fe3O4 (PCL-FO) magnetic nanofibers (MNFs) loaded with amphotericin B for treating fungal keratitis.
  • To investigate the combined effect of magnetic hyperthermia and drug release on Candida albicans viability.

Main Methods:

  • Electrospinning technique was used to fabricate PCL-FO MNFs containing amphotericin B.
  • In vitro studies assessed MNF compatibility with human mesenchymal stem cells (hMSCs) and HeLa cells.
  • The effect of MNF-induced hyperthermia and drug release on Candida albicans viability was evaluated.

Main Results:

  • The developed MNFs showed no toxicity to hMSCs and HeLa cells.
  • Magnetic hyperthermia (42°C–50°C) induced by MNFs significantly reduced Candida albicans viability.
  • Simultaneous hyperthermia and amphotericin B release from MNFs achieved near 100% Candida albicans cell death in vitro.

Conclusions:

  • Amphotericin B-loaded PCL-FO MNFs are a promising system for fungal keratitis treatment.
  • Magnetic hyperthermia can serve as an effective adjunctive therapy for fungal keratitis.
Keywords:
Fungal corneal infectionamphotericin Belectrospinninghyperthermiamagnetic nanofibers

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