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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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The role of ubiquitin-specific peptidases in cancer progression

Ming-Jer Young1, Kai-Cheng Hsu2,3,4, Tony Eight Lin3

  • 1Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, 701, Taiwan.

Journal of Biomedical Science
|May 29, 2019
PubMed

Insights

Dysregulation of protein ubiquitination contributes to cancer. This review summarizes recent findings on ubiquitin-specific proteases (USPs) in cancer progression and explores their potential as therapeutic targets for developing novel cancer treatments.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Protein ubiquitination is a key regulatory process for protein homeostasis.
  • Aberrant ubiquitination is implicated in the pathogenesis of various diseases, including cancer.
  • Deubiquitinases, particularly ubiquitin-specific proteases (USPs), play crucial roles in reversing ubiquitination.

Purpose of the Study:

  • To review the recent literature on the involvement of USPs in cancer progression.
  • To consolidate current understanding of USP functions in various cancers.
  • To discuss the therapeutic potential of targeting USPs for cancer treatment.

Main Methods:

  • Literature review of recent studies on USPs and cancer.
  • Analysis of the roles of specific USPs in cancer development and progression.
  • Exploration of USP inhibitors as a therapeutic strategy.

Main Results:

  • USPs are frequently dysregulated in cancer and significantly impact cancer progression.
  • Specific USPs have been identified as oncogenes or tumor suppressors.
  • Emerging evidence supports the development of USP inhibitors for cancer therapy.

Conclusions:

  • USPs are critical regulators in cancer biology.
  • Targeting USPs offers a promising avenue for novel cancer therapies.
  • Further research into USP inhibitors is warranted for clinical application.
Keywords:
CancerDeubiquitinasesUbiquitin-specific peptidasesUbiquitination

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