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Combining Computer Game-Based Behavioural Experiments With High-Density EEG and Infrared Gaze Tracking
Published on: December 16, 2010
Human translingual neurostimulation alters resting brain activity in high-density EEG
Zack Frehlick1, Bimal Lakhani1, Shaun D Fickling1
1HealthTech Connex, Surrey, British Columbia, Canada.
Background:
Despite growing evidence of a critical link between neuromodulation technologies and neuroplastic recovery, the underlying mechanisms of these technologies remain elusive.
Objective:
To investigate physiological evidence of central nervous system (CNS) changes in humans during translingual neurostimulation (TLNS).
Methods:
We used high-density electroencephalography (EEG) to measure changes in resting brain activity before, during, and after high frequency (HF) and low frequency (LF) TLNS.
Results:
Wavelet power analysis around Cz and microstate analysis revealed significant changes after 20 min of stimulation compared to baseline. A secondary effect of exposure order was also identified, indicating a differential neuromodulatory influence of HF TLNS relative to LF TLNS on alpha and theta signal power.
Conclusions:
These results further our understanding of the effects of TLNS on underlying resting brain activity, which in the long-term may contribute to the critical link between clinical effect and changes in brain activity.
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