[Association between serum 25-hydroxyvitamin D, parathyroid hormone, serum calcium levels and hyperglycemia]

To explore the relationship between serum 25-hydroxyvitamin D(25-OH-D), parathyroid hormone(PTH) and calcium levels and hyperglycemia.

Based on the previously studies, 621 eligible subjects were selected in this research. Demographic data, lifestyle information, history of disease and medication were collected. Height, weight and blood pressure were measured. Fasting blood glucose(FBG), 25-OH-D, PTH, calcium, phosphorus of all subjects were determined.

Compared with participants with 25-OH-D<10.0 μg/L, those with 25-OH-D between 10.0 μg/L and 19.9 μg/L and ≥20.0 μg/L had lower FBG levels and prevalence of hyperglycemia(all P<0.001). The FBG levels and prevalence of hyperglycemia were not significantly different between individuals with PTH≥65.0 ng/L and PTH<65.0 ng/L. Individuals with calcium level≤2.03 mmol/L or ≥2.54 mmol/L had higher FBG levels than those with moderate calcium level(2.03-2.54 mmol/L), however, the prevalence of hyperglycemia increased with the elevation of the calcium level. The adjusted Logistic analysis showed the risks of hyperglycemia in participants with 25-OH-D between 10.0 μg/L and 19.9 μg/L, and ≥20.0 μg/L were 0.467 times(95%CI 0.311-0.703, P<0.001), 0.402 times(95%CI 0.205-0.790, P=0.008) as that in people with 25-OH-D<10.0 μg/L, respectively. The individuals with serum calcium≥2.54 mmol/L was 1.884 times(95%CI 1.272-2.791, ) as likely to have hyperglycemia as the median calcium level 2.03-2.54 mmol/L(P=0.001).

Vitamin D deficiency and the elevated serum calcium levels may increase the risk of hyperglycemia.