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Comparison of Phototherapy in Pediatric and Adult Patients

J Magdaleno-Tapial1, J M Ortiz-Salvador1, C Valenzuela-Oñate1

  • 1Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.

Actas Dermo-Sifiliograficas
|May 29, 2019
PubMed

Insights

Phototherapy using narrowband UV-B and psoralen and UV-A (PUVA) is safe and effective for pediatric skin conditions, showing similar results to adults. Children demonstrated better treatment adherence than adults.

Area of Science:

  • Dermatology
  • Photobiology
  • Pediatric Medicine

Background:

  • Phototherapy utilizes UV radiation for treating various dermatologic conditions.
  • Established efficacy and safety in adults; emerging evidence suggests effectiveness in pediatric patients with refractory skin diseases.

Purpose of the Study:

  • To evaluate the safety and efficacy of phototherapy in pediatric patients.
  • To compare treatment outcomes and adherence between pediatric and adult phototherapy recipients.

Main Methods:

  • Retrospective study analyzing pediatric patients (<17 years) and 122 adult controls treated between 2002-2017.
  • Ninety-eight pediatric patients received phototherapy, primarily narrowband UV-B (86%) and psoralen and UV-A (PUVA) (7%).
  • Comparison of dosage, duration, and session frequency between pediatric and adult cohorts.

Main Results:

  • Common pediatric conditions treated: psoriasis (48%), vitiligo (17%), atopic dermatitis (16%).
  • Complete response rates were 35% in pediatric patients, comparable to adults.
  • Adverse effects were minimal (16%), mainly mild erythema; pediatric adherence was significantly higher than in adults (P<.05).

Conclusions:

  • Narrowband UV-B and PUVA are safe and effective pediatric phototherapy options.
  • Pediatric phototherapy protocols can mirror adult treatment regimens.
  • Children exhibit superior adherence to phototherapy compared to adult patients.
Abstract

Keywords:
Atopic dermatitisDermatitis atópicaFototerapiaNarrowband UV-BPacientes pediátricosPediatric patientsPhototherapyPhototherapy with psoralen and UV-ARadiación ultravioleta A con psoralenosRadiación ultravioleta B de banda estrechaVitiligoVitíligo

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