Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

4.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.7K
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

6.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
6.4K
Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

668
The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
The absorption exponent (ka) indicates the speed at which the drug...
668
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

2.8K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.8K
Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

9.5K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
9.5K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.3K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Higher-order interaction effects among operating conditions and feedstocks shape reactor microbiomes and fatty acid production profiles.

Bioresource technology·2026
Same author

Insects shape the cadaver decomposition microbiome and postmortem interval estimation accuracy.

mSystems·2026
Same author

Impact of pituitary pars intermedia dysfunction on inflammation within the equine reproductive tract of the mare.

Frontiers in veterinary science·2026
Same author

An animal interest approach method as a gateway to a one health educated pipeline.

Animal frontiers : the review magazine of animal agriculture·2025
Same author

CaDAVEr: a metagenome-assembled genome catalog of microbial decomposers across vertebrate environments.

Microbiology resource announcements·2025
Same author

Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression.

PLoS genetics·2025

Related Experiment Video

Updated: Jan 24, 2026

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

5.4K

Equine Fecal Microbiota Changes Associated With Anthelmintic Administration.

Isabelle G Z Kunz1, Kailee J Reed1, Jessica L Metcalf1

  • 1Department of Animal Sciences, College of Agricultural Sciences, Colorado State University, Fort Collins, CO.

Journal of Equine Veterinary Science
|May 29, 2019
PubMed
Summary
This summary is machine-generated.

Anthelmintic treatment in horses caused a minor decrease in gut microbial diversity. While some specific bacteria changed, the overall impact on the gastrointestinal microbiota was not significant, suggesting individual host factors influence responses.

Keywords:
AnthelminticGastrointestinalHelminthMicrobiomeMicrobiota

More Related Videos

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.3K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.3K

Related Experiment Videos

Last Updated: Jan 24, 2026

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

5.4K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.3K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.3K

Area of Science:

  • Equine microbiology
  • Gastrointestinal health
  • Anthelmintic drug effects

Background:

  • The gastrointestinal microbiota (GIM) is crucial for host health, and its disruption can negatively impact animals.
  • Anthelmintic drugs are widely used in horses to control parasitic infections.
  • The specific effects of these treatments on the GIM of healthy horses remain largely unknown.

Purpose of the Study:

  • To investigate the impact of a common anthelmintic drug (Quest Plus) on the fecal microbiota of horses without parasitic infections.
  • To test the hypothesis that anthelmintic administration alters the equine fecal microbiota.

Main Methods:

  • Ten horses received a single dose of Quest Plus (moxidectin and praziquantel).
  • Fecal samples were collected pre- and post-treatment.
  • Amplicon sequencing and bioinformatics analyses (QIIME2, DESeq2) were used to assess microbial changes.

Main Results:

  • A statistically significant, though small, decrease in alpha diversity of the GIM was observed post-treatment (P < .05).
  • Twenty-one specific microbial features showed significant abundance changes after anthelmintic administration (Padj < .05).
  • Beta diversity analysis did not reveal significant treatment-associated shifts, indicating individual variability in response.

Conclusions:

  • Anthelmintic treatment with Quest Plus does not appear to cause broad, large-scale disruption to the equine GIM.
  • Individual host factors likely play a significant role in determining the specific microbial responses to anthelmintics.
  • Further research into these host factors is needed to understand their influence on the host/microbiota relationship and overall horse health.