[Prevention trials and role of vascular factors in moderate arterial hypertension]

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Updated: Aug 18, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

M Safar

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |April 1, 1987
    PubMed

    Insights

    Despite lowering blood pressure in moderate arterial hypertension, coronary disease frequency remains unchanged. This highlights arterial wall alterations, not just pressure, as key to cardiovascular events in treated patients.

    Area of Science:

    • Cardiovascular Medicine
    • Hypertension Research
    • Epidemiology

    Context:

    • Epidemiological studies reveal persistent coronary disease rates in treated moderate arterial hypertension.
    • Significant arterial pressure reduction does not proportionally decrease cardiovascular events.
    • Arterial wall alterations are implicated in cardiovascular morbidity and mortality.

    Purpose:

    • To investigate the reasons behind the limited impact of arterial pressure reduction on coronary disease in treated hypertension.
    • To explore the role of main artery alterations in cardiovascular outcomes for hypertensive patients.
    • To differentiate between haemodynamic, biochemical, and drug-related factors affecting arterial health.

    Summary:

    • Treatment of moderate arterial hypertension lowers arterial pressure but shows minimal effect on coronary disease incidence.
    • Main artery alterations, including increased arterial rigidity (haemodynamic) and lipid profile changes (biochemical), contribute to cardiovascular risks.
    • These alterations may stem from hypertension-specific arterial pathology, co-existing atherosclerosis, or pharmacological effects.

    Impact:

    • Highlights the critical role of arterial wall health beyond blood pressure control in managing hypertension.
    • Suggests a need for therapeutic strategies targeting arterial structure and biochemistry in hypertensive individuals.
    • Informs clinical practice regarding the multifactorial nature of cardiovascular risk in treated hypertension.

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