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CSF Protein Concentration Shows No Correlation With Brain Volume Measures
Alexander Wuschek1,2, Sophia Grahl1,2, Viola Pongratz1,2
1Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Frontiers in Neurology
|May 29, 2019
Summary
Accounting for brain volume in cerebrospinal fluid (CSF) protein analysis did not improve diagnostic value. Correlations between CSF protein levels and brain volumes were not significant after adjusting for age and sex.
Area of Science:
- Neurology
- Neuroimaging
- Biomarker Analysis
Background:
- Cerebrospinal fluid (CSF) protein concentrations exhibit significant inter-individual variability.
- Brain volume adjustments may potentially reduce variance and enhance the diagnostic utility of CSF protein levels.
Purpose of the Study:
- To investigate the relationship between various cerebrospinal fluid (CSF) protein concentrations and brain volumes.
- To assess if incorporating brain volume metrics can improve the diagnostic value of CSF protein analysis.
Main Methods:
- Brain volumes (total intracranial, gray matter, white matter) were quantified using magnetic resonance imaging (MRI).
- CSF protein concentrations, including total protein, albumin, and albumin CSF/serum ratio, were measured.
- Data from 29 control subjects and 497 patients with clinically isolated syndrome or multiple sclerosis were analyzed.
Main Results:
- Significant positive correlations were observed between CSF protein concentrations and intracranial, gray matter, and white matter volumes.
- These correlations lost statistical significance after adjusting for age and sex.
Conclusions:
- Adjusting for brain volume, as determined by MRI, is unlikely to enhance the diagnostic value of protein concentrations in cerebrospinal fluid (CSF).
- Further research may be needed to identify other factors influencing CSF protein variability.
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