Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Processes of Self-Presentation01:29

Processes of Self-Presentation

212
Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
212
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.1K
Self-Presentation: Self-Monitoring and Self-Handicapping02:05

Self-Presentation: Self-Monitoring and Self-Handicapping

43.5K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
43.5K
Self-Presentation01:25

Self-Presentation

302
Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
302
Strategies of Self-Presentation I: Strategic Self-Presentation01:12

Strategies of Self-Presentation I: Strategic Self-Presentation

204
Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
204
Antigen Presenting Cells01:22

Antigen Presenting Cells

3.1K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Critical role of keratinocytes and protease-activated receptor 2 in secondary lymphedema development.

Clinical and translational medicine·2026
Same author

Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity.

Cancer cell·2026
Same author

Microautophagy: current understanding of its molecular mechanisms and functions.

Autophagy reports·2026
Same author

A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes.

Nature immunology·2025
Same author

Resolving the mysteries of brain clearance and immune surveillance.

Neuron·2025
Same author

Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption.

Science translational medicine·2025

Related Experiment Video

Updated: Jan 24, 2026

Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells
05:52

Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells

Published on: July 21, 2023

2.6K

The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells.

Laura Santambrogio1, Stella J Berendam2, Victor H Engelhard2

  • 1Department of Pathology, Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, United States.

Frontiers in Immunology
|May 29, 2019
PubMed
Summary

Lymphatic endothelial cells (LECs) actively participate in immune responses by processing and presenting antigens via MHC I and MHC II pathways, revealing their crucial role in immunity.

Keywords:
MHC class IMHC class IIantigen processing and presentationlymphlymphatic endothelial cells

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.9K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

11.5K

Related Experiment Videos

Last Updated: Jan 24, 2026

Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells
05:52

Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells

Published on: July 21, 2023

2.6K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.9K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

11.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Vascular Biology

Background:

  • Lymphatic endothelial cells (LECs) were historically considered passive conduits.
  • Emerging evidence highlights LECs as active immunological participants interacting with dendritic cells and T cells.
  • The molecular mechanisms of LEC antigen processing and presentation remain underexplored.

Purpose of the Study:

  • To review current knowledge on LEC antigen processing and presentation pathways.
  • To elucidate the molecular basis of LECs' role in immune responses.
  • To consolidate understanding of LECs' immunological functions.

Main Methods:

  • Literature review of existing research on LECs and antigen presentation.
  • Analysis of pathways including phagocytosis, MHC I and MHC II presentation, and cross-presentation.
  • Synthesis of data on molecular machinery involved in immune cell interactions.

Main Results:

  • LECs are involved in antigen phagocytosis and both classical and non-classical MHC II presentation.
  • Proteasome-dependent processing and MHC I presentation occur in LECs.
  • LECs engage in cross-presentation of antigens.

Conclusions:

  • LECs possess a comprehensive machinery for antigen processing and presentation.
  • These molecular capabilities underpin LECs' significant immunomodulatory roles.
  • Understanding these pathways is key to comprehending LEC-mediated immune responses.