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Rh(iii)-Catalyzed straightforward arylation of 8-methyl/formylquinolines using diazo compounds
Bidhan Ghosh1, Rajarshi Samanta
1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. rsamanta@chem.iitkgp.ac.in.
Abstract:
A straightforward Rh(iii)-catalyzed general strategy was developed for the introduction of naphthol/phenol moieties to the C(sp3)-H bond of 8-methylquinoline using diazonaphthalen-2(1H)-ones/quinone diazides. The developed method was further extended towards the arylation of 8-formylquinolines to accomplish diarylketone derivatives. The method is simple, relatively rapid, and chemo and regioselective with a wide scope and functional group tolerance. The synthetic utility was established through gram-scale synthesis and biologically active molecule construction.
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