Related Experiment Video
Updated: Jan 24, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Design of Cyclic Peptides as Protein Recognition Motifs
1Discovery Sciences, Pfizer Inc., Groton, CT, USA. ye.che@pfizer.com.
Abstract:
Protein-protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied therapeutically as protein recognition motifs only to a limited extent because of their poor permeability, decreased receptor selectivity, and proteolytic stability. A major strategy in peptide chemistry is directed toward chemical modification and macrocyclization in order to limit a peptide's conformational possibilities, to increase its chemical and enzymatic stability, to prolong the time of action, and to increase activity and selectivity toward the receptor.
Related Concept Videos
Peptide Bonds
Stereoisomerism of Cyclic Compounds
Group Design
Cyclic Processes And Isolated Systems
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state.
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
Voltammetric Techniques: Cyclic Voltammetry
Factorial Design

