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Case Report: Subacute Sclerosing Panencephalitis Presenting as Acute Encephalitis
Ravindra Kumar Garg1, Neeraj Kumar1, Imran Rizvi1
1Department of Neurology, King George's Medical University, Lucknow, India.
Abstract:
Subacute sclerosing panencephalitis (SSPE) is still a common disease in India which is characterized by a progressive mental decline, myoclonus, periodic encephalographic abnormalities, and raised anti-measles antibody titter in the cerebrospinal fluid. Acute fulminant SSPE is characterized by a rapid course of disease culminating in death, within 6 months. We report of a 10-year-old boy, who came with a 14-day history of continuous involuntary jerky movements of the left half of the body, including the head. There was a highly increased anti-measles IgG antibody titer, both in the cerebrospinal fluid and serum. We conclude that acute rapidly progressive SSPE can present as acute encephalitis syndrome.
Insights
Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disease. Acute fulminant SSPE can rapidly present as acute encephalitis syndrome, as seen in a 10-year-old boy.
Area of Science:
- Neurology
- Infectious Diseases
- Pediatrics
Background:
- Subacute sclerosing panencephalitis (SSPE) is a common, progressive neurological disease in India.
- It is characterized by mental decline, myoclonus, EEG abnormalities, and elevated anti-measles antibodies in cerebrospinal fluid.
- Acute fulminant SSPE has a rapid, fatal course within six months.
Observation:
- A 10-year-old boy presented with a 14-day history of continuous involuntary jerky movements affecting the left side of his body and head.
- The patient exhibited highly increased anti-measles IgG antibody titers in both cerebrospinal fluid and serum.
Findings:
- The case demonstrates that acute, rapidly progressive SSPE can manifest as acute encephalitis syndrome.
- Elevated anti-measles IgG titers confirmed the diagnosis in the cerebrospinal fluid and serum.
Implications:
- This presentation highlights the importance of considering SSPE in children with acute encephalitis syndrome, especially in endemic regions.
- Early recognition and diagnosis of rapidly progressive SSPE are crucial for patient management and understanding disease spectrum.
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