Case Report: Subacute Sclerosing Panencephalitis Presenting as Acute Encephalitis

Ravindra Kumar Garg1, Neeraj Kumar1, Imran Rizvi1

  • 1Department of Neurology, King George's Medical University, Lucknow, India.

Insights

Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disease. Acute fulminant SSPE can rapidly present as acute encephalitis syndrome, as seen in a 10-year-old boy.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a common, progressive neurological disease in India.
  • It is characterized by mental decline, myoclonus, EEG abnormalities, and elevated anti-measles antibodies in cerebrospinal fluid.
  • Acute fulminant SSPE has a rapid, fatal course within six months.

Observation:

  • A 10-year-old boy presented with a 14-day history of continuous involuntary jerky movements affecting the left side of his body and head.
  • The patient exhibited highly increased anti-measles IgG antibody titers in both cerebrospinal fluid and serum.

Findings:

  • The case demonstrates that acute, rapidly progressive SSPE can manifest as acute encephalitis syndrome.
  • Elevated anti-measles IgG titers confirmed the diagnosis in the cerebrospinal fluid and serum.

Implications:

  • This presentation highlights the importance of considering SSPE in children with acute encephalitis syndrome, especially in endemic regions.
  • Early recognition and diagnosis of rapidly progressive SSPE are crucial for patient management and understanding disease spectrum.

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