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Related Experiment Video

Updated: Jan 24, 2026

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity

Published on: December 17, 2017

Neurophysiological changes in simulated microgravity: An animal model.

Christiane M Nday¹, Christos Frantzidis¹, Graham Jackson²

¹Laboratory of Medical Physics, Medical School, Aristotle University of Thessaloniki (AUTh), Thessaloniki, Greece.

Neurology India

|May 29, 2019

Summary

This summary is machine-generated.

Microgravity negatively impacts astronaut neurophysiology, affecting brain pathways, neuronal connectivity, and cognitive functions. Earth-based animal models help study these effects and potential neurological disorder parallels.

Keywords:

Microgravity nervous system physiology and rodent analogs

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Area of Science:

Neuroscience
Space Physiology
Molecular Biology

Background:

Space travel poses risks to astronaut neurophysiology.
Long-duration missions can cause detrimental neurological effects.
Existing research on microgravity's impact on the nervous system is insufficient.

Purpose of the Study:

To review molecular mechanisms underlying neurophysiological changes in microgravity.
To investigate the impact of simulated microgravity on neuronal connectivity and cognitive function.
To highlight the role of biomarkers in microgravity-induced neurological alterations.

Main Methods:

Review of earth-based animal models simulating microgravity (hindlimb unloading, tail/pelvic suspension).
Analysis of molecular signaling pathways affecting neurotransmitters, genes, and receptors.
Examination of neuropathological profiles in rodent models.

Main Results:

Microgravity affects nervous system homeostasis, impacting neurotransmitter and ion channel function.
Simulated microgravity leads to reduced neuronal connectivity and impaired cognitive/neuroplasticity functions.
Animal models show neuropathological similarities to aging and neurological disorders.

Conclusions:

Earth-based animal models are valuable tools for studying microgravity's neurophysiological effects.
Understanding molecular changes is crucial for mitigating space travel's neurological risks.
Microgravity research has implications for understanding aging and neurological diseases.