Multi-component heteroarene couplings via polarity-reversed radical cascades
Jeremy M Lear1, J Quentin Buquoi, Xin Gu
1Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA. nagib.1@osu.edu.
Chemical Communications (Cambridge, England)
|May 29, 2019
Abstract:
A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N3, P(O)R2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C-C as well as C-N, C-P, and C-Rf bond formation.
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