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Serum TWEAK in acne vulgaris: An unknown soldier
Abd El-Aziz Ibrahim El-Taweel1, Rehab Mohammed Salem1, Amira Mohamed Noureldin Abdelrahman2
1Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.
Background:
TWEAK is an inflammatory cytokine which is involved in the development of many inflammatory disorders.
Aims:
This study aimed to evaluate serum levels of TWEAK in patients with acne vulgaris.
Subjects And Methods:
This case-controlled study included 100 acne vulgaris patients divided into two groups. Group 1 included 25 patients with moderate acne and 25 patients with severe acne. Group 2 consisted of 50 acne-free control subjects. Acne was graded by the Global Acne Grading System (GAGS). Serum TWEAK was measured by ELISA kits.
Results:
Acne patients had significant elevation in TWEAK serum levels when compared to the control subjects (P < 0.001). TWEAK serum levels did not show significant difference regarding disease grade, postacne scar, and hyperpigmentation (P value = 0.43, 0.37, 0.80, 0.67, respectively). TWEAK levels were not affected by any of the studied variables except for the significant negative correlation between its levels and the disease duration in severe acne group only (r = -0.42, P = 0.03).
Conclusion:
TWEAK may be involved in acne vulgaris development, but more studies are needed to clarify its role.
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