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Biologics switch in psoriasis.

Ting-Shun Wang1,2,3, Tsen-Fang Tsai3

  • 1Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan.

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|May 29, 2019
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Summary
This summary is machine-generated.

For psoriasis patients who failed previous treatments, newer biologics like IL-17 or IL-23 antagonists offer better responses. These advanced therapies are effective even after trying other biologic treatments.

Keywords:
adalimumabbiologic switchbrodalumabetanerceptguselkumabinfliximabixekizumabpsoriasissecukinumabustekinumab

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Limited guidelines exist for switching biologic therapies in psoriasis patients experiencing treatment failure.
  • While switching TNF-α antagonists is documented, data on newer biologics remains scarce.
  • Psoriasis treatment often involves sequential use of biologic agents.

Purpose of the Study:

  • To systematically review the efficacy of switching to newer biologics in psoriasis patients with treatment failure.
  • To consolidate information on biologic switching strategies involving IL-12/IL-23, IL-17A, and IL-23 antagonists.
  • To provide evidence-based insights for managing psoriasis in bio-experienced patients.

Main Methods:

  • Conducted a comprehensive systematic review of studies indexed in PubMed and Embase.
  • Included research on newer biologic agents targeting IL-12/IL-23, IL-17A, and IL-23 pathways.
  • Focused on patient populations with prior exposure to biologic therapies and treatment failure.

Main Results:

  • Newer biologics, specifically IL-17 antagonists and IL-23 antagonists, demonstrate significant efficacy in bio-experienced patients.
  • These agents show improved treatment responses compared to previous therapies in patients who have failed other treatments.
  • The review identified a growing body of evidence supporting the use of advanced biologics after treatment failure.

Conclusions:

  • IL-17 and IL-23 antagonists represent effective therapeutic options for psoriasis patients who have not responded to prior biologic treatments.
  • Biologic switching to these newer agents can lead to greater treatment success in managing refractory psoriasis.
  • Further research and clinical guidelines are warranted to optimize biologic switching strategies in psoriasis management.