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Thiamine Use in Sepsis: B1 for Everyone?
Jacob P Counts1, Victor F Rivera, Lauren A Kimmons
1College of Pharmacy (Mr Counts and Dr Kimmons) and Department of Clinical Pharmacy, Neurology and Neurosurgery (Dr Jones), University of Tennessee Health Science Center, Memphis; and Department of Pharmacy, Methodist University Hospital, Memphis, Tennessee (Drs Rivera, Kimmons, and Jones).
Critical Care Nursing Quarterly
|May 29, 2019
Summary
Thiamine, an essential nutrient, plays a key role in glucose metabolism and lactate production, impacting sepsis outcomes. This review explores thiamine
Area of Science:
- Biochemistry
- Critical Care Medicine
- Nutritional Science
Background:
- Sepsis affects millions globally, causing significant mortality.
- Novel therapeutic strategies are crucial for improving sepsis patient outcomes.
- Vitamins and nutrients are increasingly recognized for their role in sepsis management.
Purpose of the Study:
- To review current literature on thiamine's role in sepsis treatment.
- To elucidate thiamine's function in sepsis pathology and glucose metabolism.
- To guide clinicians in recognizing thiamine deficiency and implementing supplementation.
Main Methods:
- Comprehensive literature search on thiamine and sepsis.
- Analysis of studies investigating thiamine's biochemical functions.
- Synthesis of evidence regarding thiamine supplementation in sepsis.
Main Results:
- Thiamine is vital for glucose metabolism and lactate production.
- Thiamine deficiency can exacerbate sepsis-related complications.
- Evidence suggests potential benefits of thiamine supplementation in sepsis.
Conclusions:
- Thiamine plays a critical role in cellular energy metabolism relevant to sepsis.
- Recognizing and addressing thiamine deficiency is important in sepsis care.
- Further research into thiamine supplementation as an adjunct therapy for sepsis is warranted.
