Multiple Myeloma, Targeting B-Cell Maturation Antigen With Chimeric Antigen Receptor T-Cells

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Updated: Jan 24, 2026

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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Generation of Human Chimeric Antigen Receptor Regulatory T Cells

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Urvi A Shah1, Eric L Smith

  • 1From the Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Cancer Journal (Sudbury, Mass.)
|May 29, 2019
PubMed

Insights

Chimeric antigen receptor (CAR) T-cell therapies targeting B-cell maturation antigen show promise for multiple myeloma, an incurable cancer. Further research is needed to advance these novel immune therapies.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Multiple myeloma remains an incurable malignancy with significant unmet medical needs.
  • Recent advancements in therapies have been made, yet a cure has not been achieved.

Purpose of the Study:

  • To review available data on anti-B-cell maturation antigen chimeric antigen receptor (CAR) T-cell therapies for multiple myeloma.
  • To discuss the progression and next steps for these novel immune therapies.

Main Methods:

  • Review of clinical investigations and data presented at the American Society of Hematology 2018 meeting.
  • Focus on adoptive cellular therapies using CAR T-cells targeting B-cell maturation antigen.

Main Results:

  • The number of CAR T-cell trials for multiple myeloma has increased exponentially.
  • Preliminary data for anti-B-cell maturation antigen CAR T-cell therapies have generated significant enthusiasm.

Conclusions:

  • CAR T-cell therapies, particularly those targeting B-cell maturation antigen, represent a promising avenue for treating multiple myeloma.
  • Continued research and clinical investigation are crucial for advancing these therapies.

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