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Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
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Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
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Integration of Synaptic Events01:28

Integration of Synaptic Events

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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
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Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

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Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
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Related Experiment Video

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Sharing Lessons Learned to Prevent Adverse Events in Anesthesiology Nationwide.

Christina Soncrant1, Julia Neily1, Sam John T Sum-Ping

  • 1From the Veterans' Health Administration, National Center for Patient Safety, Field Office, White River Junction, Vermont.

Journal of Patient Safety
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The Veterans Health Administration

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Area of Science:

  • Anesthesiology
  • Patient Safety
  • Quality Improvement

Background:

  • The Veterans Health Administration (VHA) established a lessons learned process for anesthesia adverse events.
  • This initiative aims to alert healthcare professionals to adverse event occurrences and prevention strategies.

Purpose of the Study:

  • To detail a quality improvement project focused on anesthesia adverse events within the VHA.
  • To assess the perceived impact and usefulness of the VHA's lessons learned process.

Main Methods:

  • Root cause analyses of anesthesiology care adverse events are reported to the VHA National Center for Patient Safety.
  • National Anesthesia Service experts and the National Center for Patient Safety collaborate to review events and develop lessons learned.
  • A survey was distributed to anesthesiology chiefs in April 2018 to gauge the project's perceived usefulness and accessibility.

Main Results:

  • The survey achieved a 69% response rate.
  • 85% of respondents found the lessons learned valuable, and 90% shared them with staff.
  • 75% reported a change in patient safety behavior, with 72% gaining new patient safety knowledge and 75% gaining knowledge on preventing adverse events.

Conclusions:

  • The VHA's nationwide anesthesiology lessons learned project exemplifies a learning organization.
  • Sharing lessons learned facilitates peer-to-peer learning and proactive error prevention.
  • This process implements team and systems-based safeguards to mitigate harm from human error.