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Updated: Jan 24, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
Progression of a Buschke-Lowenstein tumor into invasive squamous cell carcinoma
Emmanuel K Fai1, Habib A Bhutta, Kashif Ali
1Emmanuel K. Fai practices in the Department of Neuroscience at the University of Maryland Medical Center Midtown Campus and in the Department of General Surgery at Laurel Regional Hospital in Laurel, Md. Habib A. Bhutta is a general surgeon in the Department of General Surgery and Kashif Ali is an oncologist in the Department of Medicine at Laurel Regional Hospital. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Buschke-Lowenstein tumors primarily are slow-growing giant condylomata accuminata of the anogenital region. They are locally destructive with a low rate of metastasis. Sexually transmitted oncogenic human papillomavirus type 6 and 11 are the greatest risk factors for Buschke-Lowenstein tumors or verrucous carcinomas, a type of squamous cell cancer. Grossly, the tumor appears as a large fungating, erythematous, cauliflower-like mass. Radical surgical excision of the tumor is the treatment of choice and close follow-up for recurrence is essential. The use of radiation or chemotherapy as adjunct treatments is controversial. This case report describes a patient with this rare condition.
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