Related Experiment Video
Updated: Jan 24, 2026
09:24
An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans
Published on: March 11, 2014
10.4K
Surviving starvation simply without TFEB.
Alexander A Soukas1,2,3, Ben Zhou1,2,3
1Department of Medicine, Diabetes Unit, and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Plos Biology
|May 29, 2019
Summary
Organisms need functional lysosomes to recover from starvation. Simple nutrients like glucose and linoleate prime lysosomal function for rapid starvation recovery in C. elegans.
Area of Science:
- Cellular Biology
- Evolutionary Biology
- Organismal Physiology
Background:
- Starvation is a major evolutionary pressure, necessitating robust survival mechanisms.
- Organisms must suppress anabolism and activate catabolism during starvation.
- Efficient recovery upon nutrient re-exposure is crucial for survival and reproduction.
Purpose of the Study:
- To investigate the role of lysosomes in starvation recovery.
- To identify specific nutrients that can prime lysosomal function for recovery.
- To understand how cells maintain readiness for growth after starvation.
Main Methods:
- Utilized Caenorhabditis elegans as a model organism.
- Exposed roundworms to specific nutrients (glucose, linoleate) during starvation.
- Assessed lysosomal function and downstream starvation recovery pathways.
Main Results:
- Exposure to glucose and linoleate primes lysosomal function.
- Lysosomal priming activates key starvation recovery pathways.
- This priming bypasses the need for master transcriptional regulators of lysosomes.
Conclusions:
- Lysosomes are critical for maintaining cellular readiness during starvation.
- Simple nutrients can directly enhance lysosomal competence for rapid recovery.
- Findings advance understanding of feast-and-famine survival strategies.
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