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Updated: Jan 24, 2026

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer
Published on: May 21, 2019
On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas
Pietro Mascheroni1, Juan Carlos López Alfonso2,3, Maria Kalli4
1Braunschweig Integrated Centre of Systems Biology and Helmholtz Center for Infectious Research, 38106 Braunschweig, Germany. pietro.mascheroni@helmholtz-hzi.de.
Abstract:
Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo-mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. We discuss how these novel findings increase the current understanding of glioma/microenvironment interactions and can contribute to new strategies for improved therapeutic outcomes.
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