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Effect of Bilastine on Diabetic Nephropathy in DBA2/J Mice

Roberta Verta1, Cristina Grange2, Maura Gurrieri3

  • 1Department of Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125 Turin, Italy. robertaverta94@gmail.com.

International Journal of Molecular Sciences
|May 30, 2019
PubMed

Insights

Bilastine, an H1 receptor antagonist, improved kidney function in diabetic mice. It protected against albuminuria and maintained glomerular filtration, suggesting potential for treating diabetic nephropathy.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic nephropathy presents a significant unmet therapeutic need.
  • Histamine H1 receptor is implicated in glomerular dysfunction due to hyperglycemia.
  • New therapeutic strategies for diabetic nephropathy are essential.

Purpose of the Study:

  • To investigate the effects of the H1 receptor antagonist bilastine on renal morphology and function.
  • To evaluate bilastine's efficacy in a murine model of streptozotocin-induced diabetes.

Main Methods:

  • Diabetes was induced in male DBA2/J mice using streptozotocin.
  • Mice received bilastine (1-30 mg/kg/day) orally for 14 weeks post-diabetes onset.
  • Renal function was assessed by measuring polyuria, albumin-to-creatinine ratio (ACR), and creatinine clearance.

Main Results:

  • Diabetic mice exhibited increased polyuria, elevated ACR, and reduced creatinine clearance.
  • Bilastine dose-dependently prevented ACR increase and restored creatinine clearance.
  • Ultrastructural analysis revealed preserved glomerular junctional integrity, with maintained expression of nephrin, P-cadherin, and synaptopodin.

Conclusions:

  • The H1 receptor may contribute to glomerular damage in diabetic nephropathy.
  • Bilastine demonstrated a protective effect on glomerular structure and function.
  • Anti-H1 antihistamines like bilastine are proposed as potential add-on therapies for diabetic nephropathy.
Keywords:
diabeteshistaminehistamine H1 receptorkidneyslit diaphragm

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