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Updated: Jan 24, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Flow Hydrodediazoniation of Aromatic Heterocycles
Liesa Röder1, Alexander J Nicholls2, Ian R Baxendale3
1Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany. liesa.roder@durham.ac.uk.
Abstract:
Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.
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