Related Experiment Video

Updated: Jan 24, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Comparison of conservative treatment with appendectomy for acute uncomplicated pediatric appendicitis: a

Le-Wee Bi1, Bei-Lei Yan1, Qian-Yu Yang1

  • 1Department of the Graduate School, Tianjin Medical University, Tianjin, PR China.

Journal of Comparative Effectiveness Research
|May 30, 2019
PubMed

Insights

Conservative treatment for pediatric appendicitis is safe and feasible, but surgery is better for cases involving fecaliths. This comparison of treatments highlights effectiveness and safety in children.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology

Background:

  • Appendicitis is a common surgical emergency in children.
  • Treatment options include conservative management and appendectomy.
  • Evidence comparing these approaches for uncomplicated cases is evolving.

Purpose of the Study:

  • To compare the effectiveness and safety of conservative treatment versus surgery for uncomplicated pediatric appendicitis.
  • To analyze treatment success rates and complication incidence.
  • To identify patient subgroups that may benefit from specific treatment modalities.

Main Methods:

  • Systematic review and meta-analysis of published studies up to September 2018.
  • Searched major medical databases including PubMed, EMBASE, and Cochrane Library.
  • Statistical analysis performed using STATA version 13.0.

Main Results:

  • Nine eligible studies were included in the analysis.
  • A significant difference in treatment success rates was observed at 1 month and 1 year.
  • No significant difference in complication incidence was found between treatment groups.
  • Conservative treatment showed low efficacy in pediatric appendicitis patients with fecaliths (p < 0.05).

Conclusions:

  • Standardized inpatient conservative treatment for pediatric appendicitis is a safe and feasible option.
  • Appendectomy is the preferred treatment for pediatric appendicitis when fecaliths are present.
  • Further research may refine treatment guidelines based on specific patient factors.

Keywords:
appendectomyconservative treatmentfecalithsmeta-analysispediatric appendicitis

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

18.6K

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
2.3K
What is Conservation Biology?01:57

What is Conservation Biology?

Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.0K
Conservation of Small Populations02:04

Conservation of Small Populations

Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
544
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.1K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.1K