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Updated: Jan 24, 2026

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
Published on: December 9, 2018
A novel symmetrical cyclooctenone from Radix Glycyrrhizae
Songsong Zhao1, Ying Zhao1, Zheng Xiang1
1School of Pharmacy, Harbin University of Commerce, Harbin, China.
Abstract:
A novel symmetrical structure, Gancao cyclooctenone A (1), was isolated from Radix Glycyrrhizae. The structure of the compound was established on the basis of the spectroscopic data including 1D and 2D NMR spectroscopy and mass spectrometry. Cytotoxic activities of compound 1 on A549 and Hela cell lines were evaluated and the IC50 values were determined to be 63.21 and 45.82 μΜ, respectively.
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