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The prenatal causes of slight lateral ventricular enlargement in healthy infants

Hideki Minowa1, Ikuyo Arai1, Hajime Yasuhara1

  • 1Department of Neonatal Intensive Care Unit, Nara Prefecture General Medical Center, Nara, Japan.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|May 30, 2019
PubMed

Insights

Maternal anemia, threatened premature labor, and diabetes mellitus are linked to slight lateral ventricular enlargement in healthy infants. This condition, observed in 45.6% of newborns, may stem from prenatal factors affecting brain development.

Area of Science:

  • Neonatal Neurology
  • Pediatric Imaging
  • Prenatal Medicine

Background:

  • Slight lateral ventricular enlargement is a finding in healthy infants.
  • Understanding its prenatal causes is crucial for early detection and intervention.

Purpose of the Study:

  • To determine the prenatal factors associated with slight lateral ventricular enlargement in healthy infants.

Main Methods:

  • A transfontanel ultrasound scan was used to assess 1089 healthy infants (≥36 weeks gestation, ≥2000g birth weight).
  • Prenatal factors were investigated for their relationship with lateral ventricular enlargement.

Main Results:

  • Slight lateral ventricular enlargement was found in 45.6% of infants.
  • Associated prenatal factors included maternal anemia (OR=1.63), threatened premature labor (OR=1.44), and diabetes mellitus (OR=2.02).
  • Infants with enlargement showed varied head circumference percentiles and heavier birth weights.

Conclusions:

  • Prenatal conditions such as maternal anemia, threatened premature labor, and diabetes mellitus can contribute to slight lateral ventricular enlargement.
  • This enlargement may indicate underlying prenatal pathological changes affecting brain development.
Abstract

Keywords:
Diabetes mellitushypoxic stressinfantsmaternal anemiathreatened premature labor

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