Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

4.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.7K
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

6.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
6.4K
Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

668
The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
The absorption exponent (ka) indicates the speed at which the drug...
668
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

2.8K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.8K
Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

9.5K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
9.5K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.3K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and predictors of sexual and physical violence during psychedelic use in a US population-based study.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same author

Fusing Specialized Surveys of Rare Populations to Larger Surveys for Generalized Inference: Cross-Sectional Survey Study.

Journal of medical Internet research·2026
Same author

Psychedelic Terminology Preference in the 2024 National Survey Investigating Hallucinogenic Trends (NSIHT).

Journal of psychoactive drugs·2026
Same author

Psilocybin Trends in States That Decriminalized Use.

JAMA·2026
Same author

Characteristics of Emergency Department Visits Among Midlife and Older Adults Screening Positive for Alcohol Misuse.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

A mixed methods assessment of an electronic health record-embedded intervention with supportive education and outreach to increase in-hospital opioid use disorder treatment initiation.

Journal of hospital medicine·2026
Same journal

Diagnostic accuracy of emergency department triage systems for predicting clinical severity: A systematic review and meta-analysis of five-level triage scales.

The American journal of emergency medicine·2026
Same journal

Methanol toxicity from inhalational abuse of a methyl acetate-containing nail polish remover.

The American journal of emergency medicine·2026
Same journal

Regarding strategies, feasibility of implementations and results of HIV screening in emergency departments.

The American journal of emergency medicine·2026
Same journal

Rocuronium dosing for rapid sequence intubation: A retrospective analysis in ED and ICU settings.

The American journal of emergency medicine·2026
Same journal

Clinical features of adults with undiagnosed acute leukemia in the emergency department: A descriptive study.

The American journal of emergency medicine·2026
Same journal

Occult intraperitoneal gynecological hemorrhage: An under-evaluated source of hemoperitoneum after blunt trauma.

The American journal of emergency medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients
11:05

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

Published on: February 6, 2021

16.8K

Does administration of haloperidol or ketorolac decrease opioid administration for abdominal pain patients? A

Kennon Heard1, Vikhyat S Bebarta1, Jason A Hoppe1

  • 1University of Colorado Department of Emergency Medicine, Section of Medical Pharmacology and Toxicology, Aurora, CO, United States of America; Rocky Mountain Poison and Drug Center, Denver, CO, United States of America.

The American Journal of Emergency Medicine
|May 30, 2019
PubMed
Summary
This summary is machine-generated.

Ketorolac modestly decreased intravenous opioid use in emergency department patients with abdominal pain, while haloperidol did not. Further research is needed to confirm these findings for routine clinical use.

More Related Videos

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.2K
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.7K

Related Experiment Videos

Last Updated: Jan 24, 2026

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients
11:05

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

Published on: February 6, 2021

16.8K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.2K
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.7K

Area of Science:

  • Emergency Medicine
  • Pharmacology
  • Clinical Research

Background:

  • Opioid use for pain management in emergency departments is a significant concern.
  • Haloperidol and ketorolac have been proposed as alternative therapies to reduce opioid consumption.
  • Non-specific abdominal pain is a common presentation in emergency settings, often requiring analgesia.

Purpose of the Study:

  • To evaluate the association between haloperidol or ketorolac administration and reduced intravenous (IV) opioid use in emergency department patients.
  • To determine if these agents impact the quantity or frequency of IV opioid administration for non-specific abdominal pain.

Main Methods:

  • Retrospective cohort study of adult patients (18-60 years) with non-specific abdominal pain.
  • Data abstracted from electronic health records, identifying cases via ICD-10 codes.
  • Nominal logistic regression used to calculate adjusted odds ratios (AOR) for IV opioid use, controlling for confounders.

Main Results:

  • Haloperidol administration was not associated with decreased IV opioid use (AOR 2.0 for any IV opioid; AOR 2.0 for >1 dose).
  • Ketorolac was associated with a modest decrease in IV opioid use (AOR 0.84 for any IV opioid; AOR 0.79 for >1 dose).
  • Study included 11,688 patients, with 4091 receiving IV opioids.

Conclusions:

  • Haloperidol does not appear to reduce IV opioid requirements in this patient population.
  • Ketorolac showed a modest benefit in reducing IV opioid use for non-specific abdominal pain.
  • High-quality studies are necessary to establish haloperidol and ketorolac as standard therapies for opioid-sparing pain management.