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Following Cell-fate in E. coli After Infection by Phage Lambda
Published on: October 14, 2011
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Systems analysis reveals complex biological processes during virus infection fate decisions
Jordi Argilaguet1, Mireia Pedragosa1, Anna Esteve-Codina2,3
1Infection Biology Laboratory, Department of Experimental and Health Sciences (DCEXS), Universitat Pompeu Fabra, Barcelona, Catalonia 08003, Spain.
Genome Research
|May 30, 2019
Summary
Understanding virus infection outcomes requires studying immune interactions. This research reveals how immune cells and communication pathways influence acute versus chronic lymphocytic choriomeningitis virus (LCMV) infections.
Area of Science:
- Immunology
- Virology
- Systems Biology
Background:
- Virus infection outcomes depend on complex virus-immune system interactions.
- Decisions leading to virus elimination or chronic infection are not fully understood.
Purpose of the Study:
- To characterize host responses during acute and chronic lymphocytic choriomeningitis virus (LCMV) infections.
- To elucidate mechanisms governing viral infection fate.
Main Methods:
- Gene coexpression network analysis of time-resolved splenic transcriptomes.
- Characterization of host response to acute and chronic LCMV infections.
Main Results:
- Early attenuation of inflammatory monocyte/macrophage observed before T cell exhaustion.
- Identified a critical role for the XCL1-XCR1 communication axis in chronic infection adaptation.
- Revealed a feedback mechanism linking T cell exhaustion and reduced effector T cell response.
Conclusions:
- The XCL1-XCR1 axis is crucial for T cell response adaptation during chronic LCMV infection.
- Findings suggest therapeutic strategies to manage chronic viral infections by controlling effector T cell responses.
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