Related Experiment Video

Updated: Jan 24, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

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HOXA11-AS promotes the progression of oral squamous cell carcinoma by targeting the miR-518a-3p/PDK1 axis

Baojun Li1, Wei Wang2, Susheng Miao1

  • 11Department of Head and Neck Surgery, The Affiliated Tumour Hospital, Harbin Medical University, Harbin, 150081 Heilongjiang People's Republic of China.

Cancer Cell International
|May 30, 2019
PubMed
Abstract

Insights

Long non-coding RNA HOXA11-AS is upregulated in oral squamous cell carcinoma (OSCC) and promotes tumor growth. The HOXA11-AS/miR-518a-3p/PDK1 axis regulates OSCC progression, offering a potential therapeutic target.

Area of Science:

  • Molecular Oncology
  • Cancer Biology

Background:

  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators in cancer.
  • HOXA11-AS is a lncRNA investigated for its role in oral squamous cell carcinoma (OSCC).

Purpose of the Study:

  • To investigate the therapeutic potential and underlying mechanism of HOXA11-AS in OSCC.
  • To elucidate the regulatory network involving HOXA11-AS in oral cancer progression.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) to assess HOXA11-AS expression in 42 OSCC tissues.
  • Bioinformatics analysis (StarBase) to identify microRNA (miRNA) interactions.
  • In vivo studies using nude mice xenograft models to evaluate HOXA11-AS effects on tumor growth.

Main Results:

  • HOXA11-AS expression was significantly upregulated in OSCC tissues compared to normal tissues.
  • HOXA11-AS promoted OSCC cell proliferation, invasion, and tumor growth in vivo.
  • HOXA11-AS targets miR-518a-3p, influencing PDK1 expression and contributing to OSCC progression.

Conclusions:

  • The HOXA11-AS/miR-518a-3p/PDK1 signaling axis is a key regulator of OSCC progression.
  • HOXA11-AS represents a potential therapeutic target for oral squamous cell carcinoma treatment.
Keywords:
HOXA11-ASOral squamous cell carcinomaPDK1miR-518a-3p

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